The Brothers García (2000)

Comedy about one big happy family and their sometimes awkward, often hilarious and ultimately beautiful milestone moments as told by its various members. Of the three siblings, middle child Matt may have just found his true love, his co-worker, Colleen; his coddled youngest brother, Greg, and his wife, Jen, are overwhelmed by the birth of their first child; and the eldest, Heather, and her husband, Tim, are dreading their impending empty nest so much, they're considering having another baby. Their parents are Joan the family's adoring matriarch who would do anything for her kids - as long as she agrees with it - and John, the gregarious patriarch who's searching for ways to soften the blow of turning 70. As the family's lives unfold in four short stories each week, they try to savor these little pieces of time that flash by but stay with you forever, because these moments add up to what life's all about.

Set in Texas, this animated series follows the life of propane salesman Hank Hill, who lives with his overly confident substitute Spanish teacher wife Peggy, wannabe comedian son Bobby, and naive niece Luanne. Hank has conservative views about God, family, and country, but his values and ethics are often challenged by the situations he, his family, and his beer-drinking neighbors/buddies find themselves in.

A family of raucous supervillains who recently ran afoul of the League of Villains and now must somehow beat a path to normalcy in a small Texas town.

The Casagrandes tells the story of Ronnie Anne, an independent, adventurous, 11-year-old who explores city life with her big, loving, multi-generational Mexican-American family.

Step by Step is an American television sitcom with two single parents, who spontaneously get married after meeting one another during a vacation, resulting in them becoming the heads of a large blended family

Teens PJ and Teddy and tween brother Gabe are typical kids -- that is, until their mother has another baby. The arrival of their new sister completely upends the entire household. When their mother heads back to work after Charlie's birth, it's up to the kids and their dad to keep the home fires burning -- and to keep Charlie out of trouble as she learns to sit up, crawl, walk and run. Teddy, as the older sister, makes a personalized video diary for Charlie, in each episode adding a nugget of wisdom for her baby sibling.

Harley is an engineering whiz who uses her inventions to navigate life as the middle child in a large family of seven kids.

The Hogan Family is an American television situation comedy that aired on NBC from March 1, 1986 to May 7, 1990, and on CBS from September 15, 1990 until July 20, 1991. It was produced by Miller-Boyett Productions, along with Tal Productions, Inc., and in association with Lorimar Productions, Lorimar-Telepictures and Lorimar Television. The show was originally titled Valerie and starred Valerie Harper as a mother trying to juggle her career with raising her three sons by her often-absent airline-pilot husband. Harper was written out of the series after the second season because of a dispute with the show's producers. Sandy Duncan joined the cast as the boys' aunt, who moved in and became their surrogate mom. During the show's third season, the series was known as Valerie's Family: The Hogans, then simply as The Hogan Family.

After her dentist husband of 20 years leaves her for his dental hygienist, Reba Hart's seemingly perfect world is turned upside down.​

The third time's the charm, they say, and reformed party girl Kate is hoping that's true when she becomes the third wife of a slightly older man, Pete. They fell into each others' arms (literally) at a karaoke bar, and flash forward a year later, Kate finds herself with an instafamily complete with three stepchildren and two ex-wives. But Kate is determined to make this work and become a part of the family no matter what.