Nina and the Neurons (2007)

Being just a normal student without a special talent, Makoto Naegi wins a lottery to attend the prestigious Hope's Peak Academy where only the top prodigies attend. However, instead of this being the beginning of a wonderful high school life, it's a ticket to despair, because the only way to graduate from Hope's Peak Academy is to kill one of your fellow students or be one of their victims.

Ichiro Sato is about as average as a student can get... except for his above-average ability to land himself in totally awkward, intensely risqué situations with his no-nonsense teacher, Kana Kojima! Ichiro has his hands full dealing with these steamy shenanigans and unexpected encounters in the most unlikely places. At least it can’t get any worse, right?

Nobunaga was a teacher who was waiting for that kind of dating sim event to happen in real life. One day, a 14 year old girl named Kicho appears in front of him, saying that she's his wife?! Apparently she came from the Warring States era and seems to have mistaken Nobunaga for the Oda Nobunaga and tells him that she wants to have his children. An age-gap love comedy featuring a teacher with a dating sims brain and a princess with a warring states era brain!!

The dark fantasy follows a high school sophomore named Akihito Kanbara. Although the boy appears human, he is half Youmu and invulnerable to wounds because he can heal quickly. One day, Akihito meets freshman Mirai Kuriyama when it seems she is about to jump from the school rooftop. Mirai is isolated because of her ability to manipulate blood, which is considered heresy among members of the spirit world. Disturbing events begin to unfold after Akihito saves Mirai.

Set six years prior to the events of Barakamon, detailing the life of Seishuu Handa as a high school student—and a very interesting life it is. In Handa-kun, Seishuu Handa is admired by his peers as a calligraphy genius and given the utmost respect, but Handa-kun himself is under the mistaken impression that the deference and attention he receives from the other students is actually bullying. Handa just wants to live a quiet life, but hilarity ensues as one character after another challenges his position as the school idol, and somehow comes away as a fan all while Handa is horrified and clueless.

Small for his age, Yukinari has been bullied and abused by girls all his life. Now in high school, he has developed a rare condition: whenever girls touch him, or even come close, he breaks out in hives. Imagine his surprise, when he is suddenly transported to the city of Seiren on a mystic world invisibly orbiting the Earth, and populated with vast numbers of women and very few men. Fortunately, he has a new friend, Miharu-chan, whose touch inexplicably doesn't affect him.

Shikada Kokonotsu's father owns a rural sweets shop, and his plan is for Kokonotsu to take it over one day. However, Kokonotsu wants to be a manga author instead! One day in summer, the cute but weird girl Shidare Hotaru, from the famous sweets company, comes to pay a visit. Apparently, Kokonotsu's father is famous and she wants him to join her family's company. However, he will only agree if she can convince Kokonotsu to take over the family business!

Oreimo follows the daily life of an ordinary high school boy named Kyousuke Kousaka. Kyousuke’s younger sister Kirino is a pretty fashion model, but also hides a dark secret of being an otaku of adult games. Kyousuke is the only person to whom Kirino reveals her hidden obsession and other issues.

A secret life is the one thing they have in common. At school, Hori is a prim and perfect social butterfly, but the truth is she's a brash homebody. Meanwhile, under a gloomy facade, Miyamura hides a gentle heart, along with piercings and tattoos. In a chance meeting, they both reveal a side they've never shown. Could this blossom into something new?

Shinichi Sakurai’s one wish is for a little peace and quiet. But Hana Uzaki — his boisterous, well-endowed underclassman — has other plans. All she wants is to hang out and poke fun at him. With the help of her chipper charm and peppy persistence, this might just be the start of a beautiful relationship!