Malcolm in the Middle (2000)

Crank up the 8-track and flash back to a time when platform shoes and puka shells were all the rage in this hilarious retro-sitcom. For Eric, Kelso, Jackie, Hyde, Donna and Fez, a group of high school teens who spend most of their time hanging out in Eric’s basement, life in the ‘70s isn’t always so groovy. But between trying to figure out the meaning of life, avoiding their parents, and dealing with out-of-control hormones, they’ve learned one thing for sure: they’ll always get by with a little help from their friends.

The whacky adventures of Ned Bigby and his best pals Moze and Cookie at James K. Polk Middle School, as "every-kid" Ned shatters the fourth wall to share tips and tricks on navigating middle school or junior high hurdles. Ned's not super cool, and he has no superpowers. He is, however, witty, well-groomed, upbeat and self-aware. Moreover, with more than a little help from his two best friends, he's equipped to conquer middle school minefields. From crushing bullies to crushes, from off- the-wall, mean and cool teachers to pop quizzes, elections and detentions, Ned knows that nothing, including the seventh grade, is as bad as it seems, and friendship matters most.

Al Bundy is an unsuccessful middle aged shoe salesman with a miserable life and an equally dysfunctional family. He hates his job, his wife is lazy, his son is dysfunctional (especially with women), and his daughter is dim-witted and promiscuous.

The daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the city of Orson, Indiana.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

Physicists Leonard and Sheldon find their nerd-centric social circle with pals Howard and Raj expanding when aspiring actress Penny moves in next door.

In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.

Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

That flashy girl from Flushing with the heart of an angel (and the voice of a slighty more nasal angel). The comic misadventures of the sweet and sassy Fran Fine, her sophisticated employer, Broadway producer Mr. Sheffield, his boisterous brood and his wisecracking staff.

Will, a street-smart teenager, moves from the tough streets of West Philly to posh Bel-Air to live with his Uncle Philip, Aunt Vivian, his cousins — spoiled Hilary, preppy Carlton and young Ashley — and their sophisticated British butler, Geoffrey. Though Will’s antics and upbringing contrast greatly with the upper-class lifestyle of his extended relatives, he soon finds himself right at home as a loved part of the family.