Malcolm in the Middle (2000)

A comedy about two young couples and their outrageously contrasting views on parenting. Greg and Kim Warner struggle on a daily basis to become perfect at the job. Kim is a neurotic, stay-at-home mother, and although her husband, Greg, is a success in his career, his more difficult job is keeping his wife calm as they raise their two young children. While Kim is determined to be the perfect mother and perfect wife and to raise the perfect children, her sister, Christine Hughes, a very down-to-earth mother of two, continually reminds her that life will never be perfect. Christine's husband, Jimmy, often feels compelled to share with his brother-in-law his philosophy about being a husband and a parent while still remaining a man.

The early life of child genius Sheldon Cooper, later seen in The Big Bang Theory.

Clarissa Darling is a teen girl dealing with typical pre-adolescent concerns such as school, boys, pimples, wearing her first training bra and an annoying little brother Ferguson.

A fresh and funny take on modern friendship and what one urban family will do to stay friends after the perfect couple who brought them all together break up on their wedding day. The failed wedding forces them all to question their life choices. Then there are Alex and Dave themselves, who strike a truce and must learn to live with the changes their breakup has brought.

Brothers Shawn and Marlon are on the lookout for money and success, though the two are complete opposites. Shawn is responsible and conservative while Marlon is free-spirited and liberal. They are not immune to sibling rivalry, but frequently enjoy being each other's partner in crime.

Will, a street-smart teenager, moves from the tough streets of West Philly to posh Bel-Air to live with his Uncle Philip, Aunt Vivian, his cousins — spoiled Hilary, preppy Carlton and young Ashley — and their sophisticated British butler, Geoffrey. Though Will’s antics and upbringing contrast greatly with the upper-class lifestyle of his extended relatives, he soon finds himself right at home as a loved part of the family.

A family comedy narrated by Katie, a strong-willed mother, raising her flawed family in a wealthy town filled with perfect wives and their perfect offspring.

A family man struggles to gain a sense of cultural identity while raising his kids in a predominantly white, upper-middle-class neighborhood.

T.J. is a boy genius who gets bumped up from the fourth grade to high school. T.J. tries to adjust to his new life, but he shares some classes with his 14 year-old brother Marcus, the school jock, and his clueless and self-absorbed 16 year-old sister Yvette.

The everyday life of Moesha Mitchell, a vivacious young woman juggling romance, school, ever-changing family dynamics, and friendships.