Charlotte Vandermeersch (born 11 November, 1983; Oudenaarde) is a Belgian actress and director.

Charlotte Vandermeersch graduated in 2005 from the Herman Teirlinck Institute in Antwerp as a Master in Dramatic Art. She has played in numerous theater productions with, among others, SKaGeN, Wunderbaum and Abattoir Fermé. Together with Maaike Neuville she made her own theater production "The Kiss of the Spider Woman.

In the early years she mainly played supporting and guest roles. However, in 2010, she landed two lead roles, in the television series "Day and Night" and in the movie "Turquaze" . In 2012, she played the lead role in the television series "Deadline 14/10" as well as in its sequel, "Deadline 25/5", which was shown on VTM in the spring of 2014. That year she also played the role of Linda Schools in the feature film Bowling Balls. In 2016 she had a leading role in "Belgica" by Felix Van Groeningen. In addition, from 2012 to 2020 she was permanently affiliated with the theater group LAZARUS.

She is in a relationship with film director Felix Van Groeningen. In May 2018, they had a son together, Rufus.