Lisa Jane Persky (born May 5, 1955) is an American actress.

Persky was born in New York City, New York, the daughter of Jane Holley (née Wilson) and Mort Persky. She grew up in New York's Greenwich Village and attended the High School of Art and Design.

She debuted as Robert Duvall's daughter in The Great Santini and went on to act in such movies as American Pop, The Big Easy, When Harry Met Sally..., Coneheads, KISS Meets the Phantom of the Park, and Peggy Sue Got Married.

She wrote for New York Rocker magazine in the 1970s and dated former Blondie bass player Gary Valentine Lachman. On January 19, 2008, she married music historian and former co-star of the Comedy Central game show Beat the Geeks Andy Zax.

In 2009 and 2010, Persky began making appearances on The Best Show on WFMU radio program, as both as a regular caller and as an in-studio special guest.

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