Born in Boulogne-Billancourt, Île-de-France, and raised in Porto Vecchio, Corsica, Frédéric Testot began on Fun Radio, with Éric Judor and Ramzy Bedia (Éric et Ramzy), before appearing on Radio Nova in Jamel Debbouze's program where he met Omar Sy for the first time, in 1997.

Together, they began their television career on Canal+ on Debbouze's program, Le Cinéma de Jamel. They created Le Visiophon, d'Omar et Fred, Les sketches d'Omar et Fred and Les coming-nexts.

After a two-year hiatus, the duo returned in 2005 with a show called Service après-vente des émissions (English: "After-sales service of TV shows"). From 2006 to 2012, it became a famous daily column of Le Grand Journal, hosted by Michel Denisot.

Testot then played in several comedy movies, including Sur la piste du Marsupilami (2012), The Big Bad Wolf (2013) and Arrête ton cinéma (2016), and starred in the Netflix Original Series La Mante in 2017.