Brigitte Sy (born 26 January 1956) is a French actress and filmmaker. Her directorial film debut, Les Mains libres, was released in 2010 to critical acclaim in France.

She is the mother of the actors Louis Garrel and Esther Garrel whom she had with the director Philippe Garrel. In an Arte short film collection about AIDS awareness, she revealed that she has been HIV-positive since 1990, contracted from a partner who previously had a drug addiction. She also addresses the issue in Les mains libres and L'endroit idéal where the protagonist, Barbara (played by Ronit Elkabetz), is HIV-positive. She opposes the feminist #MeToo movement (#BalanceTonPorc in France) and signed an anti-metoo letter in Le Monde, on 9 January 2018, arguing that men have the freedom to harass (importuner) women.

She is of Sephardic Jewish descent.

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