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Dana Wheeler-Nicholson (born New York City, New York, October 9, 1960) is an American actress.

Sometimes credited as Dana Wheeler Nicholson, she has appeared in numerous movies, but is probably best known for her role in Fletch as Gail Stanwyk (wife of the villain and love interest of the title character played by Chevy Chase) and in Tombstone (1993) as Mattie Blaylock (Wyatt Earp's common law wife). Her most recent movie role was in Fast Food Nation (2006). She has also appeared in several TV series including Seinfeld, Law & Order, Law & Order: Criminal Intent, Sex and the City, Boston Public, Boston Legal, Friday Night Lights, and most recently The Good Guys.

She is the granddaughter of pioneering American comic book publisher Malcolm Wheeler-Nicholson.

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