Andrea Di Stefano (born 15 December 1972) is an Italian actor.

Born in Rome, he moved to New York City to study acting at the Actor's Studio. In the U.S. he played in Smile, an independent movie directed by Andrew Hunt.

He played the leading role in the 1997 film Il principe di Homburg directed by Marco Bellocchio and entered into the 1997 Cannes Film Festival. He has played in films such as Il fantasma dell'opera by Dario Argento, Almost blue by Alex Infascelli, and Angela by Roberta Torre.

Lately he played the role of Giancarlo in the movie Cuore Sacro directed by Ferzan Özpetek.

Andrea Di Stefano has also appeared in many TV episodes. In 1999 with the role of Fabrizio Canepa in Ama il tuo nemico by Damiano Damiani. In 2006 he played in the TV movie I colori della gioventù directed by Gianluigi Calderone and in the most recent Medicina generale broadcast in the spring 2007 in which he played Giacomo Pogliani, a talented doctor in a big Roman hospital.