Vincenzo Ferrera was born in Palermo. He has shown an interest in acting since he was a teenager. Ferrera started taking part in theater organizations immediately after high school. He entered the world of entertainment with the Teatro Biondo school and with the Gruppo della Rocca. In 2008, he participated in the Rai 3 soap opera Agrodolce, in the role of Stefano Martorana.

Ferrera also appeared in the film Borsellino's angels in 2003, directed by Rocco Casareo, in the role of Vincenzo Li Muli, the miniseries An almost perfect dad, directed by Maurizio Dell'Orso, broadcast by Rai 1, in which he was co-protagonist with Michele Placido, Il capo dei capi, in the role of Commissioner Beppe Montana, broadcast in 2007 on Canale 5,The thirteenth apostle, The young Montalbano, Un posto al sole, in the role of Eduardo Nappi and Utopia in the role of Mino Pecorelli. In Mare fuori is the educator Beppe Romano while in Survivors he is Gaetano Russo.