Liis Karpov (until 2016 Liis Laigna; born on September 28, 1984 in Häädemeeste) is an Estonian actress.

She has studied piano at the Kilingi-Nõmme Music School for eight years (1991–1999). She graduated from Kilingi-Nõmme High School in 2003 and continued her studies at the Viljandi Academy of Culture in the same year, and in 2007 she completed the VI flight of acting studies at the University of Tartu's Viljandi Academy of Culture. The instructor of the course was Kalju Komissarov. In 2016, she graduated cum laude from Tartu Tervishoiu College of Nursing.

From 2007 to 2012, she was an actor with Endla, from 2012 to 2016 she was a freelancer. Since 2016, she has been an actress at theater Endla again.