Koula Agagiotou (Greek: Κούλα Αγαγιώτου; 1915 – 25 October 2006) was a Greek actress. She is probably best known for her role in the Greek sitcom To Retire.

Agagiotou's real name was Angeliki. She appeared in more than fifty films, including a well-received performance in the 1971 film Evdokia. Her last appearance was in To Retire. Agagiotou was married and had a daughter. Agagiotou made her film debut in 1951. She mostly appeared in dramas, and during the 1980s she participated in cult comedies such as Kamikazi Agapi Mou alongside Stathis Psaltis.