Lana Wilson is an Emmy-winning and two-time Spirit Award-nominated writer and director. Transformative quests for meaning and humanity connect her diverse body of work across documentaries, short films, and episodic. Her most recent film, the Taylor Swift documentary Miss Americana (2020), was the opening night film of the 2020 Sundance Film Festival and is a Netflix Original. Miss Americana was a New York Times Critic's Pick, an IndieWire Critic's Pick, and was named one of the Five Best Documentaries of the Year by the National Board of Review.

Wilson's previous feature film, The Departure (2017), about a punk-turned-priest in Japan, was critically acclaimed for being a poetic, profound, and moving exploration of what makes life worth living. The Departure premiered at the Tribeca Film Festival in 2017, played at festivals around the world, and was nominated for the Independent Spirit Award for Best Documentary. The Departure was called "A work of art" by the San Francisco Chronicle, "A genuinely spiritual experience" by the Washington Post, and "Tender and moving...like a haiku" by the New York Times. The film was acquired by FilmRise and theatrically released in 30 US cities, beginning with a held-over run at New York's Metrograph. The Departure has a rare 100% rating on Rotten Tomatoes, indicating "universal acclaim."

Wilson's first film, After Tiller (2013), goes inside the lives of the four most-targeted abortion providers in the country, taking a powerful and complex look at one of the most incendiary issues of our time. After Tiller premiered at the Sundance Film Festival in 2013, and went on to win an Emmy Award for Best Documentary. It was also nominated for the Independent Spirit Award for Best Documentary, four Cinema Eye Honors, a Satellite Award, and the Ridenhour Prize. After Tiller was acquired by Oscilloscope and released in theaters in 50 US cities. The film was named one of the five best documentaries of the year by the National Board of Review, and featured in "Best of 2013" lists in the LA Times, Village Voice, Indiewire, Artforum, and more. Flavorwire named it one of the "50 Best Documentaries of All Time."

Wilson also works in episodic and short-form filmmaking. She created and directed A Cure for Fear (2018), a short-form series about a groundbreaking scientist that played at SXSW and was nominated for the 2019 International Documentary Association Award for Best Short-Form Series.