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Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.

A boy tries to stop aliens that have taken over his town and are brainwashing its inhabitants.

A series of down-on-their-luck individuals enter the decrepit and spine-chilling Rialto theater, only to have their deepest and darkest fears brought to life on the silver screen by The Projectionist – a mysterious, ghostly figure who holds the nightmarish futures of all who attend his screenings.

A former special forces agent is trapped in a time loop and relives his death over and over again. To escape the terrible situation, he must track down those responsible and stop them.

Thomas Jacobs invents a way to watch people's memories from the inside. Going against his morals, he accepts an offer to enter a heroin addict's memories to literally see if he committed a crime. However,a malfunction causes his consciousness to become trapped inside the criminal's mind. He remains a prisoner in the addict's memories for more than four years until he discovers the possibility of escape.

Five train passengers are joined by a mysterious fortuneteller who offers to read Tarot. A quintet of stories unfold: an architect returns to his ancestral home to find a vengeful werewolf; a doctor suspects his new wife is a vampire; an intelligent vine takes over a house; a jazz musician plagiarises music from a voodoo ceremony; and a pompous art critic is pursued by a disembodied hand.

When professional gamer Hana, who suffers from acute agoraphobia, receives new equipment that enhances her game, she begins to wonder if it is reading her mind – or controlling it.

When Polly receives a mysterious box, it comes with one rule: place inside something she needs, something she hates, and something she loves. If she doesn’t obey, it will consume everything—and everyone—she’s ever known.

Charles Dexter Ward, a wealthy scientist, uses an ancient diary and human remains to begin a terrifying and bloody pursuit for immortality.

After losing his wife and his memory in a car accident, a single father undergoes an experimental treatment that causes him to question who he really is.