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H.P. Lovecraft anthology is divided into four segments: "The Library" which is the wraparound segment involving Lovecraft's research into the Book of The Dead and his unwitting release of a monster and his writing of the following horror segments "The Drowned", "The Cold", and "Whispers".

In the middle of a routine patrol, officer Daniel Carter happens upon a blood-soaked figure limping down a deserted stretch of road. He rushes the young man to a nearby rural hospital staffed by a skeleton crew, only to discover that patients and personnel are transforming into something inhuman. As the horror intensifies, Carter leads the other survivors on a hellish voyage into the subterranean depths of the hospital in a desperate bid to end the nightmare before it's too late.