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Driven by the fact that there are few things more dangerous than a prisoner who has just escaped, and tired of following protocol and resorting to outdated methods of law enforcement, veteran U.S. Marshals Charlie Duchamp and Ray Zancanelli are taking an unorthodox approach to their work: using former fugitives to catch fugitives.

Narumi Katou is a middle-aged man who suffers from the bizarre ZONAPHA Syndrome: a rare and inexplicable disease that causes its victims to endure severe seizures at random, with the only cure being to watch someone laugh. One day, during Narumi's part time job, a young boy with a giant suitcase fleeing from three adults runs into him. The boy introduces himself as Masaru Saiga, the new owner of the famous Saiga Enterprises following his father's recent death. However, other members of his family are trying to assassinate him and claim the fortune for themselves.