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Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".

When his brother disappears, a man visits the remote country house where he was last seen. While the host seems outwardly friendly and his niece more demonstrably so, there's a feeling of menace in the air with the overhanging legend of Lavinia Morley, the Black Witch of Greymarsh.