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After the previous Godzilla attack, a miniature arms race ensues to collect his cells. Concerned over Godzilla's possible return, the Japanese government uses the cells to create a new bio-weapon, ANEB (Anti-Nuclear Energy Bacteria). They seeks the aid of geneticist Genshiro Shiragami, who's experiments result in a new mutation.

Vampire death dealer Selene fends off brutal attacks from both the Lycan clan and the Vampire faction that betrayed her. With her only allies, David and his father Thomas, she must stop the eternal war between Lycans and Vampires, even if it means she has to make the ultimate sacrifice.