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A story of two coalitions – ACT UP and TAG (Treatment Action Group) – whose activism and innovation turned AIDS from a death sentence into a manageable condition. Despite having no scientific training, these self-made activists infiltrated the pharmaceutical industry and helped identify promising new drugs, moving them from experimental trials to patients in record time.

Torture chambers, acid vats, greased chutes and gassing rooms were just some of the devices of death designed by the Torture Doctor, H.H. Holmes in his castle of horrors. Follows Holmes' entire life as a criminal mastermind.